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Forming a group of European PhD students specialized in the development of sustainable production methods for the pharmaceutical sector – this is the goal of GreenDigiPharma (“Green and digital continuous-flow pharmaceutical manufacturing”), the new “doctoral network” financed by the European Commission within the Marie Skłodowska-Curie programme, and coordinated by prof. Gianvito Vilé, researcher at the “Giulio Natta” Department of Chemistry, Materials and Chemical Engineering of the Politecnico di Milano.
Therefore, the purpose of GreenDigiPharma is to create a group of highly qualified PhDs that will operate in the academic as well as in the industrial world to introduce new skills, fundamental to guide the green and digital transformation of pharmaceutical production.
GreenDigiPharma will train the leaders of tomorrow in the pharmaceutical industry, who will propose innovative solutions able to simultaneously increase the productivity of this sector, improve its competitiveness and reduce its environmental impact.
Professor Gianfranco Vilé, coordinator of GreenDigiPharma
In addition to the Politecnico di Milano, the project involves 9 other European universities, 8 industrial partners and a research body.
The SupraBioNano Lab (SBNLab) at the Politecnico di Milano’s Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, in partnership with the University of Bologna and the Aalto University of Helsinki (Finland) has, for the first time, synthesised a superfluorinated gold nanocluster, made up of a core of only 25 gold atoms, to which 18 branch-structured fluorinated molecules are linked.
The metal clusters are an innovative class of very complex nanomaterial, characterised by ultra-small dimensions (<2nm) and peculiar chemical-physical properties such as luminescence and catalytic activity, which encourage its application in various scientific fields of high importance in relation to modern global challenges. These include precision medicine, in which metal nanoclusters are used as innovative probes for diagnostic and therapeutic applications, and the energy transition, where they are applied as efficient catalysers for the production of green hydrogen.
The crystallisation of metal nanoclusters offers the possibility of obtaining high-purity samples, allowing their fine atomic structure to be determined; however, at present this remains a very difficult process to control. The methodologies developed in this study promoted the crystallisation of nanoclusters, allowing their atomic structure to be determined. The end result is the structural description of the most complex fluorinated nano-object ever reported.
The atomic structure has been determined by means of x-ray diffraction at the Sincrotrone Elettra in Trieste. It will soon be possible to study the structure of these advanced nanomaterials at the Politecnico di Milano, where – thanks also to the grant from the Region of Lombardy – Next-GAME (Next-Generation Advanced Materials), a laboratory dedicated to the use of state-of-the-art x-ray instruments to characterise crystals, nanoparticles and colloids, is being established.
Among the authors of the study were Prof. Pierangelo Metrangolo, Prof. Giancarlo Terraneo, Prof. Valentina Dichiarante, Prof. Francesca Baldelli Bombelli, Dr. Claudia Pigliacelli (SBNLab); professor Giulio Cerullo, from the Politecnico di Milano’s Department of Physics, also contributed to the study, looking at the nanocluster’s optical characteristics and demonstrating the fluorinated binders’ impact on the gold core’s optical activity.
The project “Training school on modelling compound climate-related events” has won a grant of 10,000 euros as a T.I.M.E. project.
June and July 2021 have been characterised by extraordinary natural events, like the heatwave occurred on the Pacific Coast of the United States and Canada, and the flood event occurred in Northern Europe. These events extended over rather large spatial and temporal scales, and manifested with cascading effects, interconnected behaviours and hazards. They are classified as “compound climate-related events”.
They are an emerging topic in science for the enormous impact on society. Compound climate-related events can pose serious threats to natural systems and human societies. Modelling and predicting compound events require knowledge on advanced statistical methods.
The project proposes a Training School on Modelling Compound climate-related Events to train the next generation of researchers and scientists to deal with such complex and impactful events. The school, targeted for PhD students, will be two weeks long, and provide tools and methodologies to investigate compound events. In addition, there will be ample time to work on scientific projects organized in four small groups and socialize with the other participants and lecturers.
The coordinator of the project is the Politecnico di Milano, Department of Civil and Environmental Engineering, with Prof. Carlo De Michele as principal investigator. The project involves also Technische Universität Dresden (Germany) and Vrije Universiteit Brussel (Belgium).
The T.I.M.E. Association (Top International Managers in Engineering), founded in 1989, is a network of leading technical universities and engineering schools in Europe and all over the world, with a strong international dimension in teaching, research and industrial relations. The association currently consists of 57 members in 25 countries, and the Politecnico di Milano is a member of the Advisory Committee.
Besides double degree activities, T.I.M.E. promotes a series of other initiatives, including the T.I.M.E. projects, through which the association co-finances new or existing initiatives between member universities, in which T.I.M.E. can represent an added value.
Tag: landfill, energy, hydrogen, animal waste, biomass, biogas, sustainable, green, methane, steam, decarbonization Researcher: Giampaolo Manzolini Department: DENG – Energy Department
The use of hydrogen as an energy source could reduce both pollution and the production of greenhouse gases. However, most of the hydrogen currently produced comes from natural gas, coal or oil, processing all of which creates carbon dioxide. Biomass, though, is an almost carbon-neutral renewable energy source. The anaerobic digestion process of residual biomass from various sources – animal waste, sewage treatment plants, industrial wastewater and landfills, for example – produces biogas, a mixture of methane and carbon dioxide. Politecnico di Milano has an important focus on this matter. One of the most promising technologies developed by our researchers comes from the European project BIONICO (BIOgas membrane reformer for deceNtralIzed hydrogen produCtiOn), funded with over 3 million euros under the Horizon 2020 scheme.
The team developed, assembled and is currently testing a pilot plant that converts biogas directly into hydrogen, with a novel reactor concept at its core. The plant is expected to produce 100 kg of hydrogen per day. It will be the first example of a biogas-to-hydrogen plant based on membrane reactor technology installed in a real biogas plant at this scale, with more than 100 membranes in a single fluidised bed membrane reactor. It aims at a hydrogen production efficiency of 70%, 10% over same-size conventional reactors. It works with biogas produced through biodigesters or from municipal waste, fed into the plant together with steam inside the reactor. The reaction is enhanced by a catalyst which circulates in the reactor through the same flow of biogas. Inside the reactor, palladium tubular membranes on ceramic support allow to selectively separate the hydrogen. The high efficiency obtained with the BIONICO reactor is guaranteed from the simultaneous production and separation of hydrogen in a single reactor. The use of a single reactor operating at temperatures limited (550 vs 800 ° C) also allows to simplify the system, with potential cost advantages over traditional systems.
The project shows the feasibility and cost-effectiveness of the solution and define the market potential for the new plant, while proving biogas-produced hydrogen to be a viable sustainable energy source, with potential environmental benefits that can come from using such plants in the long term.
The BIONICO consortium benefits from the cooperation of eight partners from seven different countries across the EU. Each partner has been involved in a different aspect of the mission, such as the design and testing of the reactor together with the main system components. The BIONICO project stems from the knowledge gained in years of research from three previous projects: ReforCELL, FERRET and FluidCELL.
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