in silico – Politecnico di Milano

ReBone, a Doctoral Network coordinated by Politecnico di Milano and funded by the European Union within the Marie Skłodowska-Curie Actions (MSCA) has kicked off. Young researchers involved will develop innovative technologies for creating customised 3D-printed bone replacement implants based on bioactive ceramics.

The ultimate goal is to provide clinical experts with the tools to produce customised bone graft substitutes, allowing for individualised therapeutic solutions for each patient in terms of mechanical and mechanical-biological performance, surgical implantability and reliability of the manufacturing process.

In addition, ReBone will develop state-of-the-art in silico models, based on advanced computational methods and characterisation and validation techniques, for customised implants with a visualisation system for mixed-reality surgical planning.

ReBone is a European project funded under the Horizon Europe programme that will enrol 10 young researchers in as many European PhD schools. The project intersects many disciplines including materials engineering, 3D printing technology of ceramic material devices, biomechanics, biology and augmented reality,
Pasquale Vena, professor of Industrial Bioengineering at the Department of Chemistry, Materials and Chemical Engineering ‘Giulio Natta’ and coordinator of the project

In addition to Politecnico di Milano, ReBone involves partners from eight European countries: Politecnico di Torino (Italy), Università del Piemonte Orientale (Italy), University of Liège (Belgium), Lithoz (Austria), Ludwig Boltzmann Institute of Osteology (Austria), University of Salzburg (Austria), Department of Technology and Metallurgy, University of Belgrade (Serbia) MedApp (Poland), EU CORE Consulting (Italy), Cerhum (Belgium), Science on the Street (Slovenia), University of Tampere (Finland), Université Paris-Est Créteil (France), AUVA Trauma Centre Meidling (Austria).

For further information and to participate in the PhD programme, please visit the ReBone website or contact Pasquale Vena, project coordinator (pasquale.vena@polimi.it).

The actions of the European project GEMINI officially started, funded by the European Union under the HORIZON program.

The project, lasting for 6 years, aims to create a new approach to revolutionize the treatment of patients affected by cerebral strokes. A digital twin will be developed to simulate the various possible treatments for a patient suffering from ischemic stroke or cerebral haemorrhage, thereby guiding clinicians in making the best therapeutic choices.

The team from the Politecnico di Milano, the Italian lead of the project, consists of researchers from the Laboratory of In Silico Medicine of the Department of Chemistry, Materials, and Chemical Engineering ‘Giulio Natta’, who boasts extensive experience in the field of numerical simulation of medical devices.

The anticipated contribution will lead to the development of a digital tool based on results obtained from computer simulations, allowing for a detailed study of various phases of clinical treatment, such as the removal of blood clots from cerebral vessels and the possible fragmentation that may occur.

The project has received funding of 10 million euros, involves 19 partners, and will be coordinated by the University Medical Center of the University of Amsterdam. The countries involved are: France, Germany, Ireland, the Netherlands, Poland, Taiwan, Spain, the United States, Switzerland, and Hungary.

Tag: in silico

ReBone: designing customised bone replacement implants

GEMINI: project for stroke treatment