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raman – Progress in Research

The microscope that reveals the chemical composition of samples

An international research team co-ordinated by the Institute for Photonics and Nanotechnologies of the National Research Council in Milan (CNR-IFN) and involving researchers from Politecnico di Milano’s Department of Physics, Columbia University and Stanford University, has developed an innovative optical microscope capable of producing detailed images of the chemical composition of a sample more effectively compared to the systems currently in use. The result has been published in the journal Optica.

This instrument represents a major breakthrough in the field of microscopy and spectroscopy, opening up new perspectives for research in the materials and life sciences. Indeed, it will be able to contribute to the study of innovative two-dimensional materials and to the characterisation of microplastics found in the environment and within animal tissues.

The benefits of the microscope stem from the unprecedented combination of two techniques, Raman spectroscopy and Fourier transform spectroscopy. The developed method allows Raman and fluorescence maps to be acquired in up to 100 times less time than with traditional instruments and to measure all sample points at the same time and with high efficiency, acquiring more data simultaneously.

A revolution in the diagnosis and treatment of cancer

CHARM is a project aiming to develop a medical device based on high-speed, low-cost Raman digital imaging technology and artificial intelligence to transform cancer diagnosis and treatment.

The technology will analyse the molecular composition of patient tissue samples to distinguish cancerous from healthy cells without the need for chemical staining.

CHARM’s Raman imaging technology uses graphene-based ultra-fast fibre lasers to generate digital images of patient tissue for automatic analysis by artificial intelligence to support diagnosis. Because the images are digital, they can be viewed remotely, allowing histopathologists to work more efficiently and to support regions and countries short of qualified staff. The technology also potentially opens the way for personalised treatments for cancer.

The partners involved are Cambridge Raman Imaging Ltd. (CRI), a polimi spin-off, the University of Cambridge, Consiglio Nazionale delle Ricerche, Politecnico Di Milano, the Jena University Hospital (Germany) and the firms INsociety (Italy) and Inspiralia (Spain). The project coordinator is Dr Matteo Negro, CRI’s Chief Technology Officer.

CHARM is one of the 42 projects selected for a €3.3 million funding from 292 submitted in the first ever EIC (European Innovation Council) Transition Challenges, intended to support moving technologies from laboratories into the real world. The EIC is Europe’s flagship innovation programme to identify, develop and scale up breakthrough technologies and game changing innovations. In the case of CHARM, it aims to develop medical devices to the preclinical validation phase.

Politecnico di Milano, who pioneered the high-speed Raman imaging technology, will be responsible for the development of the microscope and the detection system.

I am excited to contribute to the translation of the results of our scientific studies into a commercial product which promises to significantly improve cancer diagnosis and therapy and have an important societal impact. To foster a close link between fundamental research and technological innovation is one of our main missions as academics and lies at the core of the EIC.

Prof. Giulio Cerullo, head of the ultrafast spectroscopy laboratory at Politecnico di Milano

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