In the next few years, High Performance Computing and Quantum technologies will be pushing forward the frontiers of science and innovation. Politecnico di Milano is a key player in the field of the second quantum revolution. From particles science to light-matter interactions to quantum mechanics, our H.P.C and Quantum research centre is a hub for partnerships with worldwide universities and industry, at the core of the challenge to unlock the potential of a new generation of quantum technologies to bring transformative advances to science, industry and society. Politecnico di Milano is a member of Quantum Flagship.